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Cellosaurus MCF-7/SB-T-0035R (CVCL_C0CU)

[Text version]
Cell line name MCF-7/SB-T-0035R
Synonyms MCF7/SB-T-0035R
Accession CVCL_C0CU
Resource Identification Initiative To cite this cell line use: MCF-7/SB-T-0035R (RRID:CVCL_C0CU)
Comments Population: Caucasian.
Characteristics: Generated by step-increasing drug concentration to 300 nm of SB-T-0035. Overexpresses ABCB1 which is amplified and inserted in chromosome 19 (PubMed=29625142; Direct_author_submission).
Doubling time: ~25-30 hours (Direct_author_submission).
Selected for resistance to: SB-T-0035 (Stony-Brooke Taxane 35).
Miscellaneous: Doubling time, ABCB1 status and STR profile from personal communication of Daniel, Petr.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO10
D2S133821,23
D3S135816
D5S81811,12
D7S8209,10
D8S117910,14
D13S31711
D16S53911,12
D18S5114
D19S43313,14
D21S1130
FGA23,25
TH016
TPOX9,12
vWA14,15

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Publications

PubMed=29625142; DOI=10.1016/j.taap.2018.04.002; PMCID=PMC5937276
Jelinek M., Balusikova K., Daniel P., Nemcova-Furstova V., Kirubakaran P., Jacek M., Wei L.-F., Wang X., Vondrasek J., Ojima I., Kovar J.
Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.
Toxicol. Appl. Pharmacol. 347:79-91(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0CU
Encyclopedic resources Wikidata; Q112930091
Entry history
Entry creation23-Jun-2022
Last entry update10-Sep-2024
Version number7