Cellosaurus cell line Abcam LNCaP clone FGC TMPRSS2 KO (CVCL

Cross-references
Cell line name	Abcam LNCaP clone FGC TMPRSS2 KO
Synonyms	Human TMPRSS2 knockout LNCaP
Accession	CVCL_C0BI
Resource Identification Initiative	To cite this cell line use: Abcam LNCaP clone FGC TMPRSS2 KO (RRID:CVCL_C0BI)
Comments	Group: SARS-CoV-2 research cell line. Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11876; TMPRSS2. Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations	Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line). Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1379 (LNCaP clone FGC)
Sex of cell	Male
Age at sampling	50Y
Category	Cancer cell line
Cell line collections (Providers)	Abcam; ab273745
Cell line databases/resources	cancercelllines; CVCL_C0BI
Encyclopedic resources	Wikidata; Q112928360
Entry history
Entry creation	23-Jun-2022
Last entry update	19-Dec-2024
Version number	7