ID   UPCI-SCC-152
AC   CVCL_C058
SY   UPCI:SCC152; UPCISCC152; SCC152
DR   ATCC; CRL-3240
DR   Cell_Model_Passport; SIDM00398
DR   DepMap; ACH-001228
DR   Wikidata; Q54991684
RX   PubMed=17112776;
RX   PubMed=24403267;
RX   PubMed=26045983;
RX   PubMed=28236344;
RX   PubMed=29156801;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 2 days (PubMed=29156801).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051.
ST   Source(s): ATCC=CRL-3240; PubMed=29156801
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 12,13
ST   D5S818: 11,12
ST   D7S820: 9,10
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C4043; Hypopharyngeal squamous cell carcinoma
DI   ORDO; Orphanet_494547; Squamous cell carcinoma of the hypopharynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1899 ! UPCI-SCC-090
SX   Male
AG   47Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 02-05-24; Version: 19
//
RX   PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001;
RA   White J.S., Weissfeld J.L., Ragin C.C.R., Rossie K.M., Martin C.L.,
RA   Shuster M., Ishwad C.S., Law J.C., Myers E.N., Johnson J.T.,
RA   Gollin S.M.;
RT   "The influence of clinical and demographic risk factors on the
RT   establishment of head and neck squamous cell carcinoma cell lines.";
RL   Oral Oncol. 43:701-712(2007).
//
RX   PubMed=24403267; DOI=10.1002/cam4.151;
RA   Kawakami H., Okamoto I., Terao K., Sakai K., Suzuki M., Ueda S.,
RA   Tanaka K., Kuwata K., Morita Y., Ono K., Nishio K., Nishimura Y.,
RA   Doi K., Nakagawa K.;
RT   "Human papillomavirus DNA and p16 expression in Japanese patients with
RT   oropharyngeal squamous cell carcinoma.";
RL   Cancer Med. 2:933-941(2013).
//
RX   PubMed=26045983;
RA   Ziemann F., Arenz A., Preising S., Wittekindt C., Klussmann J.P.,
RA   Engenhart-Cabillic R., Wittig A.;
RT   "Increased sensitivity of HPV-positive head and neck cancer cell lines
RT   to X-irradiation +/- cisplatin due to decreased expression of E6 and
RT   E7 oncoproteins and enhanced apoptosis.";
RL   Am. J. Cancer Res. 5:1017-1031(2015).
//
RX   PubMed=28236344; DOI=10.1002/hed.24729;
RA   Walline H.M., Goudsmit C.M., McHugh J.B., Tang A.L., Owen J.H.,
RA   Teh B.T., McKean E.L., Glover T.W., Graham M.P., Prince M.E.P.,
RA   Chepeha D.B., Chinn S.B., Ferris R.L., Gollin S.M., Hoffmann T.K.,
RA   Bier H., Brakenhoff R.H., Bradford C.R., Carey T.E.;
RT   "Integration of high-risk human papillomavirus into cellular
RT   cancer-related genes in head and neck cancer cell lines.";
RL   Head Neck 39:840-852(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//