ID   PC-6
AC   CVCL_C002
SY   PC 6; PC6
DR   EFO; EFO_0002845
DR   CGH-DB; 105-1
DR   CGH-DB; 9051-4
DR   ChEMBL-Cells; CHEMBL3307571
DR   ChEMBL-Targets; CHEMBL614235
DR   Cosmic; 1212199
DR   Cosmic; 1571745
DR   PubChem_Cell_line; CVCL_C002
DR   Wikidata; Q54938461
RX   PubMed=2982333;
RX   PubMed=3731100;
RX   PubMed=9259410;
RX   PubMed=10912951;
RX   PubMed=12107105;
RX   PubMed=15185009;
RX   PubMed=17237272;
RX   PubMed=17511773;
RX   PubMed=18445659;
RX   PubMed=21128075;
CC   From: Immuno-Biological Laboratories (IBL); Tokyo; Japan.
CC   Population: Japanese.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 21-03-23; Version: 15
//
RX   PubMed=2982333;
RA   Terashima M., Inoue K., Mukaiyama T., Mitsui I., Ogawa M.;
RT   "Enhanced cytotoxic effect of adriamycin and vincristine against PC-6
RT   (human lung cancer cell line) and Hattori (human breast cancer cell
RT   line).";
RL   Gan To Kagaku Ryoho 12:343-347(1985).
//
RX   PubMed=3731100;
RA   Hanai N., Shitara K., Yoshida H.;
RT   "Generation of monoclonal antibodies against human lung squamous cell
RT   carcinoma and adenocarcinoma using mice rendered tolerant to normal
RT   human lung.";
RL   Cancer Res. 46:4438-4443(1986).
//
RX   PubMed=9259410; DOI=10.1002/(SICI)1097-0215(19970807)72:4<680::AID-IJC21>3.0.CO;2-E;
RA   Joto N., Ishii M., Minami M., Kuga H., Mitsui I., Tohgo A.;
RT   "DX-8951f, a water-soluble camptothecin analog, exhibits potent
RT   antitumor activity against a human lung cancer cell line and its
RT   SN-38-resistant variant.";
RL   Int. J. Cancer 72:680-686(1997).
//
RX   PubMed=10912951; DOI=10.1097/00001813-200006000-00005;
RA   Ishii M., Iwahana M., Mitsui I., Minami M., Imagawa S., Tohgo A.,
RA   Ejima A.;
RT   "Growth inhibitory effect of a new camptothecin analog, DX-8951f, on
RT   various drug-resistant sublines including BCRP-mediated camptothecin
RT   derivative-resistant variants derived from the human lung cancer cell
RT   line PC-6.";
RL   Anticancer Drugs 11:353-362(2000).
//
RX   PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7; PMCID=PMC1850681;
RA   Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T.,
RA   Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S.,
RA   Inazawa J.;
RT   "A novel target gene, SKP2, within the 5p13 amplicon that is
RT   frequently detected in small cell lung cancers.";
RL   Am. J. Pathol. 161:207-216(2002).
//
RX   PubMed=15185009; DOI=10.1007/s00262-004-0533-9; PMCID=PMC11034254;
RA   Yamaji H., Iizasa T., Koh E., Suzuki M., Otsuji M., Chang H.,
RA   Motohashi S., Yokoi S., Hiroshima K., Tagawa M., Nakayama T.,
RA   Fujisawa T.;
RT   "Correlation between interleukin 6 production and tumor proliferation
RT   in non-small cell lung cancer.";
RL   Cancer Immunol. Immunother. 53:786-792(2004).
//
RX   PubMed=17237272; DOI=10.1158/1535-7163.MCT-06-0529;
RA   Oguri T., Bessho Y., Achiwa H., Ozasa H., Maeno K., Maeda H., Sato S.,
RA   Ueda R.;
RT   "MRP8/ABCC11 directly confers resistance to 5-fluorouracil.";
RL   Mol. Cancer Ther. 6:122-127(2007).
//
RX   PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x; PMCID=PMC11159702;
RA   Fukuyama T., Ichiki Y., Yamada S., Shigematsu Y., Baba T., Nagata Y.,
RA   Mizukami M., Sugaya M., Takenoyama M., Hanagiri T., Sugio K.,
RA   Yasumoto K.;
RT   "Cytokine production of lung cancer cell lines: correlation between
RT   their production and the inflammatory/immunological responses both in
RT   vivo and in vitro.";
RL   Cancer Sci. 98:1048-1054(2007).
//
RX   PubMed=18445659; DOI=10.1158/1535-7163.MCT-07-2088;
RA   Oguri T., Ozasa H., Uemura T., Bessho Y., Miyazaki M., Maeno K.,
RA   Maeda H., Sato S., Ueda R.;
RT   "MRP7/ABCC10 expression is a predictive biomarker for the resistance
RT   to paclitaxel in non-small cell lung cancer.";
RL   Mol. Cancer Ther. 7:1150-1155(2008).
//
RX   PubMed=21128075; DOI=10.1007/s00280-010-1533-4;
RA   Takakuwa O., Oguri T., Ozasa H., Uemura T., Kasai D., Miyazaki M.,
RA   Maeno K., Sato S.;
RT   "Over-expression of MDR1 in amrubicinol-resistant lung cancer cells.";
RL   Cancer Chemother. Pharmacol. 68:669-676(2011).
//