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Cellosaurus LAZ-149 (CVCL_BT08)

[Text version]
Cell line name LAZ-149
Synonyms LAZ 149; LAZ149; GM10610
Accession CVCL_BT08
Resource Identification Initiative To cite this cell line use: LAZ-149 (RRID:CVCL_BT08)
Comments From: Lazarus, Herbert; Dana-Farber Cancer Institute; Boston; USA.
Population: African American.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:4823; HBA1; Zygosity=Heterozygous (Coriell=GM10610).
  • Gene deletion; HGNC; HGNC:4827; HBB; Zygosity=Homozygous (Coriell=GM10610).
Disease Beta thalassemia (NCIt: C34375)
Beta-thalassemia major (ORDO: Orphanet_231214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=947544; DOI=10.1016/0092-8674(76)90161-6
Forget B.G., Hillman D.G., Lazarus H., Barell E.F., Benz E.J. Jr., Caskey C.T., Huisman T.H.J., Schroeder W.A., Housman D.E.
Absence of messenger RNA and gene DNA for beta-globin chains in hereditary persistence of fetal hemoglobin.
Cell 7:323-329(1976)

PubMed=6196781; DOI=10.1073/pnas.80.22.6937; PMCID=PMC390101
Tuan Lo D., Feingold E., Newman M., Weissman S.M., Forget B.G.
Different 3' end points of deletions causing delta beta-thalassemia and hereditary persistence of fetal hemoglobin: implications for the control of gamma-globin gene expression in man.
Proc. Natl. Acad. Sci. U.S.A. 80:6937-6941(1983)

CLPUB00447
Mulivor R.A., Suchy S.F.
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

Cross-references
Cell line collections (Providers) Coriell; GM10610
Cell line databases/resources CLO; CLO_0024280
Biological sample resources BioSample; SAMN00800101
Encyclopedic resources Wikidata; Q54901982
Entry history
Entry creation02-May-2016
Last entry update19-Dec-2024
Version number16