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Cellosaurus Abcam THP-1 NLRP3 KO (CVCL_B9Z7)

[Text version]
Cell line name Abcam THP-1 NLRP3 KO
Synonyms Human NLRP3 knockout THP-1
Accession CVCL_B9Z7
Resource Identification Initiative To cite this cell line use: Abcam THP-1 NLRP3 KO (RRID:CVCL_B9Z7)
Comments Population: Japanese.
Knockout cell: Method=CRISPR/Cas9; HGNC; 16400; NLRP3.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Abcam; ab280063
Cell line databases/resources cancercelllines; CVCL_B9Z7
Encyclopedic resources Wikidata; Q112929036
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number5