Cellosaurus cell line Abcam MCF-7 DGCR8 KO (CVCL

Cross-references
Cell line name	Abcam MCF-7 DGCR8 KO
Synonyms	Human DGCR8 knockout MCF7
Accession	CVCL_B8UT
Resource Identification Initiative	To cite this cell line use: Abcam MCF-7 DGCR8 KO (RRID:CVCL_B8UT)
Comments	Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:2847; DGCR8. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease	Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0031 (MCF-7)
Sex of cell	Female
Age at sampling	69Y
Category	Cancer cell line
Cell line collections (Providers)	Abcam; ab287367
Cell line databases/resources	cancercelllines; CVCL_B8UT
Encyclopedic resources	Wikidata; Q112928463
Entry history
Entry creation	23-Jun-2022
Last entry update	19-Dec-2024
Version number	6