• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
  

PubMed=18288110; DOI=10.1038/nbt1393
Kroon E.J., Martinson L.A., Kadoya K., Bang A.G., Kelly O.G., Eliazer S., Young H.Y., Richardson M., Smart N.G., Cunningham J., Agulnick A.D., D'Amour K.A., Carpenter M.K., Baetge E.E.
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo.
Nat. Biotechnol. 26:443-452(2008)

PubMed=22623968; DOI=10.1371/journal.pone.0037004; PMCID=PMC3356395
Schulz T.C., Young H.Y., Agulnick A.D., Babin M.J., Baetge E.E., Bang A.G., Bhoumik A., Cepa I., Cesario R.M., Haakmeester C., Kadoya K., Kelly J.R., Kerr J., Martinson L.A., McLean A.B., Moorman M.A., Payne J.K., Richardson M., Ross K.G., Sherrer E.S., Song X.-H., Wilson A.Z., Brandon E.P., Green C.E., Kroon E.J., Kelly O.G., D'Amour K.A., Robins A.J.
A scalable system for production of functional pancreatic progenitors from human embryonic stem cells.
PLoS ONE 7:E37004-E37004(2012)

PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175
Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C., Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G., Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A., Eggan K.C.
Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations.
Nature 545:229-233(2017)