Cellosaurus cell line UM4-6 (CVCL

Cellosaurus UM4-6 (CVCL_B840)

Cross-references
Cell line name	UM4-6
Accession	CVCL_B840
Resource Identification Initiative	To cite this cell line use: UM4-6 (RRID:CVCL_B840)
Comments	From: University of Michigan; Ann Arbor; USA. Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-12-0147. Omics: Genomics; Whole exome sequencing. Omics: Transcriptomics; RNAseq. Omics: Variations; SNP array analysis. Donor information: Embryo is sibling to those giving rise to UM4-9 (Cellosaurus=CVCL_5H77), UM4-11 (Cellosaurus=CVCL_5H75), UM4-12 (Cellosaurus=CVCL_5H76) and UM4-13 (Cellosaurus=CVCL_WW08). Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358. Cell type: Embryonic stem cell; CL=CL_0002322.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Blastocyst stage
Category	Embryonic stem cell
Web pages	Info; U-M; -; https://record.umich.edu/articles/a3647-new-stem-cell/ Provider; MStem Cell; -; https://www.mstemcell.org/purchase-stem-cell-lines/
Publications	PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175 Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C., Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G., Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A., Eggan K.C. Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations. Nature 545:229-233(2017) PubMed=30158855; DOI=10.3389/fnmol.2018.00282; PMCID=PMC6104480 Haenfler J.M., Skariah G., Rodriguez C.M., Monteiro da Rocha A., Parent J.M., Smith G.D., Todd P.K. Targeted reactivation of FMR1 transcription in fragile X syndrome embryonic stem cells. Front. Mol. Neurosci. 11:282.1-282.17(2018) PubMed=31374463; DOI=10.1016/j.scr.2019.101504; PMCID=PMC6736695 Moore L.R., Keller L., Bushart D.D., Delatorre R.G., Li D.-J., McLoughlin H.S., do Carmo Costa M., Shakkottai V.G., Smith G.D., Paulson H.L. Antisense oligonucleotide therapy rescues aggresome formation in a novel spinocerebellar ataxia type 3 human embryonic stem cell line. Stem Cell Res. 39:101504-101504(2019)
Cell line databases/resources	NIHhESC; NIHhESC-12-0147
Encyclopedic resources	Wikidata; Q54991044
Gene expression databases	GEO; GSM3053264 GEO; GSM3053265
Entry history
Entry creation	06-Jun-2012
Last entry update	10-Apr-2025
Version number	18