Cellosaurus cell line Abcam THP-1 TYROBP KO (CVCL

Cross-references
Cell line name	Abcam THP-1 TYROBP KO
Synonyms	Human TYROBP (DAP12) knockout THP-1
Accession	CVCL_B7TG
Resource Identification Initiative	To cite this cell line use: Abcam THP-1 TYROBP KO (RRID:CVCL_B7TG)
Comments	Population: Japanese. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:12449; TYROBP. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line). Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line). Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease	Childhood acute monocytic leukemia (NCIt: C9163) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0006 (THP-1)
Sex of cell	Male
Age at sampling	1Y
Category	Cancer cell line
Cell line collections (Providers)	Abcam; ab273726
Cell line databases/resources	cancercelllines; CVCL_B7TG
Encyclopedic resources	Wikidata; Q112929100
Entry history
Entry creation	23-Jun-2022
Last entry update	19-Dec-2024
Version number	6