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Cellosaurus ACN/IFN-gamma (CVCL_B7TC)

[Text version]
Cell line name ACN/IFN-gamma
Accession CVCL_B7TC
Resource Identification Initiative To cite this cell line use: ACN/IFN-gamma (RRID:CVCL_B7TC)
Comments Problematic cell line: Probably contaminated. Parent cell line (ACN) has been shown to probably be a melanoma cell line.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 5438; IFNG.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Asn184fs*6 (c.545_546insA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Phe113Ser (c.338T>C); ClinVar=VCV000823709; Zygosity=Homozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1068 (ACN)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=15150552; DOI=10.1038/sj.bjc.6601842; PMCID=PMC2409504
Airoldi I., Meazza R., Croce M., Di Carlo E., Piazza T., Cocco C., D'Antuono T., Pistoia V., Ferrini S., Corrias M.V.
Low-dose interferon-gamma-producing human neuroblastoma cells show reduced proliferation and delayed tumorigenicity.
Br. J. Cancer 90:2210-2218(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7TC
Encyclopedic resources Wikidata; Q112929124
Entry history
Entry creation23-Jun-2022
Last entry update10-Sep-2024
Version number5