| Cell line name |
HCT116-A2 |
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| Accession |
CVCL_B7PU |
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| Resource Identification Initiative |
To cite this cell line use: HCT116-A2 (RRID:CVCL_B7PU) |
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| Comments |
Population: Caucasian.
Doubling time: 25.0 hours (PubMed=21619602).
Selected for resistance to: ChEBI; CHEBI_8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11986; TOP1; Simple; p.Leu617Ile (c.1849C>A); Zygosity=Homozygous (PubMed=21619602).
|
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_B7PT (HCT116-s) |
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| Sex of cell |
Male |
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| Age at sampling |
48Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=21619602; DOI=10.1186/1476-4598-10-64; PMCID=PMC3120799
Gongora C., Vezzio-Vie N., Tuduri S., Denis V., Causse A., Auzanneau C., Collod-Beroud G., Coquelle A., Pasero P., Pourquier P., Martineau P., Del Rio M.
New topoisomerase I mutations are associated with resistance to camptothecin.
Mol. Cancer 10:64.1-64.13(2011) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_B7PU
|
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| Encyclopedic resources |
Wikidata; Q112929646
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| Entry history |
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| Entry creation | 23-Jun-2022 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 6 |
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