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Cellosaurus JcTaxWT-Neo7 (CVCL_B7PR)

[Text version]
Cell line name JcTaxWT-Neo7
Accession CVCL_B7PR
Resource Identification Initiative To cite this cell line use: JcTaxWT-Neo7 (RRID:CVCL_B7PR)
Comments Population: Caucasian.
Transfected with: UniProtKB; P03409; Human T-cell leukemia virus 1 (HTLV-1) Tax.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=9357968
Ohtsubo H., Arima N., Matsushita K., Hidaka S., Fujiwara H., Arimura K., Kukita T., Fukumori J., Matsumoto T., Eizuru Y., Tanaka H.
Human T lymphotropic virus-type I Tax induction of CD21/Epstein-Barr virus receptor expression on T cells and its significance in leukemogenesis of adult T cell leukemia.
Exp. Hematol. 25:1246-1252(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7PR
Encyclopedic resources Wikidata; Q112929893
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number5