| Cell line name |
JcTaxWT-Neo7 |
|---|
| Accession |
CVCL_B7PR |
|---|
| Resource Identification Initiative |
To cite this cell line use: JcTaxWT-Neo7 (RRID:CVCL_B7PR) |
|---|
| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03409; Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) tax.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0065 (Jurkat) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
14Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=9357968
Ohtsubo H., Arima N., Matsushita K., Hidaka S., Fujiwara H., Arimura K., Kukita T., Fukumori J., Matsumoto T., Eizuru Y., Tanaka H.
Human T lymphotropic virus-type I Tax induction of CD21/Epstein-Barr virus receptor expression on T cells and its significance in leukemogenesis of adult T cell leukemia.
Exp. Hematol. 25:1246-1252(1997) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_B7PR
|
|---|
| Encyclopedic resources |
Wikidata; Q112929893
|
|---|
| Entry history |
|---|
| Entry creation | 23-Jun-2022 |
|---|
| Last entry update | 19-Dec-2024 |
|---|
| Version number | 7 |
|---|
