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Cellosaurus SRD-5 (CVCL_B7PG)

[Text version]
Cell line name SRD-5
Synonyms Sterol Regulatory Defective-5
Accession CVCL_B7PG
Resource Identification Initiative To cite this cell line use: SRD-5 (RRID:CVCL_B7PG)
Comments Selected for resistance to: ChEBI; CHEBI:42977; 25-hydroxycholesterol.
Transformant: ChEBI; CHEBI:23995; N-ethyl-N-nitrosourea (ENU).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Mutation; UniProtKB; P97260; Scap; Simple; p.Leu315Phe (c.943C>T); Zygosity=Heterozygous (PubMed=12482938).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_D893 (CHO-7)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=12482938; DOI=10.1073/pnas.262669399; PMCID=PMC139202
Yabe D., Xia Z.-P., Adams C.M., Rawson R.B.
Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.
Proc. Natl. Acad. Sci. U.S.A. 99:16672-16677(2002)

Cross-references
Encyclopedic resources Wikidata; Q112930423
Entry history
Entry creation23-Jun-2022
Last entry update30-Jan-2024
Version number5