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Cellosaurus A549/TS1 (CVCL_B7N5)

[Text version]
Cell line name A549/TS1
Accession CVCL_B7N5
Resource Identification Initiative To cite this cell line use: A549/TS1 (RRID:CVCL_B7N5)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:12441; TYMS.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=21487406; DOI=10.1038/bjc.2011.129; PMCID=PMC3101907
Takezawa K., Okamoto I., Okamoto W., Takeda M., Sakai K., Tsukioka S., Kuwata K., Yamaguchi H., Nishio K., Nakagawa K.
Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer.
Br. J. Cancer 104:1594-1601(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7N5
Encyclopedic resources Wikidata; Q112927065
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number7