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Cellosaurus MCF-7 PRODH KO (CVCL_B7K1)

[Text version]
Cell line name MCF-7 PRODH KO
Synonyms MCF7POX-KO; PRODH/POX CRISPR/Cas9 knockout MCF7
Accession CVCL_B7K1
Resource Identification Initiative To cite this cell line use: MCF-7 PRODH KO (RRID:CVCL_B7K1)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:9453; PRODH.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=35409177; DOI=10.3390/ijms23073813; PMCID=PMC8998922
Kazberuk A., Chalecka M., Palka J., Bielawska K., Surazynski A.
NSAIDs induce proline dehydrogenase/proline oxidase-dependent and independent apoptosis in MCF7 breast cancer cells.
Int. J. Mol. Sci. 23:3813.1-3813.18(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7K1
Encyclopedic resources Wikidata; Q112930089
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number6