ID   MC-BR-BTY-0019
AC   CVCL_B7K0
DR   Wikidata; Q112930075
RX   PubMed=34145270;
CC   Characteristics: Established from a nude mouse xenograft (PubMed=34145270).
CC   Characteristics: ER-negative, PR-negative, ERBB2-positive (PubMed=34145270).
CC   Doubling time: 24-48 hours (PubMed=34145270).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34145270).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=34145270).
CC   Sequence variation: Gene deletion; HGNC; HGNC:6844; MAP2K4; Zygosity=Homozygous (PubMed=34145270).
CC   Sequence variation: Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Leu2088Profs*11 (c.6261_6262insC); Zygosity=Heterozygous (PubMed=34145270).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Trp146Ter (c.438G>A); ClinVar=VCV000428890; Zygosity=Homozygous (PubMed=34145270).
CC   Omics: Deep exome analysis.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
ST   Source(s): PubMed=34145270
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 9,11
ST   D16S539: 9,12
ST   D18S51: 14
ST   D21S11: 27,28
ST   D3S1358: 15,17
ST   D5S818: 10,11
ST   D7S820: 11
ST   D8S1179: 8,12
ST   FGA: 19,23.2
ST   Penta D: 8,12
ST   Penta E: 11
ST   TH01: 6,9.3
ST   TPOX: 8
ST   vWA: 18,19
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 19-12-24; Version: 7
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RX   PubMed=34145270; DOI=10.1038/s41523-021-00285-x; PMCID=PMC8213738;
RA   Zhuang Y.-X., Grainger J.M., Vedell P.T., Yu J., Moyer A.M.,
RA   Gao H.-Y., Fan X.-Y., Qin S.-S., Liu D., Kalari K.R., Goetz M.P.,
RA   Boughey J.C., Weinshilboum R.M., Wang L.-W.;
RT   "Establishment and characterization of immortalized human breast
RT   cancer cell lines from breast cancer patient-derived xenografts
RT   (PDX).";
RL   NPJ Breast Cancer 7:79.1-79.12(2021).
//