Cellosaurus cell line PC-B-142CA (CVCL

Cellosaurus PC-B-142CA (CVCL_B7I1)

[Text version]

Cell line name

PC-B-142CA

Accession

CVCL_B7I1

Resource Identification Initiative

To cite this cell line use: PC-B-142CA (RRID:CVCL_B7I1)

Comments

Population: Southeast Asian; Thai.
Characteristics: ER-negative, PR-negative, ERBB2-positive.
Doubling time: 45 +- 3 hours (PubMed=34651665).
Karyotypic information: 38 chromosomes with a chr X monosomy (PubMed=34651665).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.

Sequence variations

Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Pro871Leu (c.2612C>T); ClinVar=VCV000041812; Zygosity=Homozygous (PubMed=34651665).
Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ser425Cys (c.1274C>G); Zygosity=Homozygous (PubMed=34651665).
Mutation; HGNC; HGNC:1101; BRCA2; Simple; c.7806-14T>C; ClinVar=VCV000126158; Zygosity=Homozygous (PubMed=34651665).
Mutation; HGNC; HGNC:6342; KIT; Simple; p.Glu839Lys (c.2515G>A); ClinVar=VCV000013862; Zygosity=Heterozygous (PubMed=34651665).
Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Cys420Arg (c.1258T>C); ClinVar=VCV000031945; Zygosity=Heterozygous (PubMed=34651665).
Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln224Ter (c.670C>T); Zygosity=Homozygous (PubMed=34651665).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile232Thr (c.695T>C); ClinVar=VCV000141224; Zygosity=Homozygous (PubMed=34651665).

Disease

Breast carcinoma (NCIt: C4872)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

58Y

Category

Cancer cell line

STR profile

Source(s): PubMed=34651665

Markers:

CSF1PO	9,12
D2S1338	16,24
D3S1358	16
D5S818	12
D7S820	11
D8S1179	13
D13S317	8
D16S539	12,13
D18S51	14
D19S433	14,14.2
D21S11	31.2
FGA	24
TH01	7,9.3
TPOX	8
vWA	17

Publications

PubMed=34651665; DOI=10.3892/or.2021.8205; PMCID=PMC8548790
Thongchot S., Jamjuntra P., Prasopsiri J., Thuwajit P., Sawasdee N., Poungvarin N., Warnnissorn M., Sa-nguanraksa D., O-Charoenrat P., Yenchitsomanus P.-T., Thuwajit C.
Establishment and characterization of novel highly aggressive HER2-positive and triple-negative breast cancer cell lines.
Oncol. Rep. 46:254.1-254.13(2021)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_B7I1

Encyclopedic resources

Wikidata; Q112930252

Entry history

Entry creation

23-Jun-2022

Last entry update

19-Dec-2024

Version number