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Cellosaurus MPT-S1 (CVCL_B7GV)

[Text version]
Cell line name MPT-S1
Accession CVCL_B7GV
Resource Identification Initiative To cite this cell line use: MPT-S1 (RRID:CVCL_B7GV)
Comments Population: Chinese.
Characteristics: Established from a nude mouse xenograft.
Doubling time: 2-3 days (PubMed=35365682).
Omics: Deep exome analysis.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; HGNC:7133; KMT2D; Simple; c.6079_6082delAATT; Zygosity=Heterozygous (PubMed=35365682).
  • Mutation; HGNC; HGNC:11957; MED12; Simple; p.Gly44Asp (c.131G>A); ClinVar=VCV000092220; Zygosity=Heterozygous (PubMed=35365682).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; c.1530_1531delAG; Zygosity=Heterozygous (PubMed=35365682).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; c.1588_1589delAA; Zygosity=Heterozygous (PubMed=35365682).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu252del (c.754_756delCTC); ClinVar=VCV000998484; Zygosity=Heterozygous (PubMed=35365682).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.750_754delinsA; Zygosity=Heterozygous (PubMed=35365682).
Disease Malignant breast phyllodes tumor (NCIt: C4504)
Phyllodes tumor of the breast (ORDO: Orphanet_180261)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): PubMed=35365682

Markers:
AmelogeninX
CSF1PO12
D1S165611,16
D2S44112
D2S133823
D3S135815,16
D5S81811
D7S82012
D8S117911,13
D10S124813,14
D12S39121
D13S3179,12
D16S53910,11
D18S5118
D19S43313.2
D21S1129,30
D22S104514
DYS3919
FGA19
Penta D9,14
Penta E11,19
TH019
TPOX8,9
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=35365682; DOI=10.1038/s41523-022-00413-1; PMCID=PMC8975864
Ng D.Y.X., Li Z.-M., Lee E., Kok J.S.T., Lee J.Y., Koh J., Ng C.C.-Y., Lim A.H., Liu W., Ng S.R., Lim K.S., Huang X.X., Hong J.H., Guan P.-Y., Sim Y.-R., Thike A.A., Md Nasir N.D., Li S., Tan P.H., Teh B.T., Chan J.Y.-S.
Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor.
NPJ Breast Cancer 8:44.1-44.7(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7GV
Encyclopedic resources Wikidata; Q112930125
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number6