ID   HC-04.J7
AC   CVCL_B7D7
DR   ArrayExpress; E-MTAB-6919
DR   cancercelllines; CVCL_B7D7
DR   PRIDE; PXD008613
DR   Wikidata; Q112929640
RX   PubMed=30891005;
CC   Group: Malaria research cell line.
CC   Problematic cell line: Possibly contaminated. Parent cell line (HC-04) has been shown to have an STR profile identical to that of Hep-G2.
CC   Population: Caucasian.
CC   Characteristics: Compared to the parent cell line, has an inscreased susceptibility to Plasmodium falciparum sporozoite invasion (PubMed=30891005).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Omics: Deep proteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_Z631 ! HC-04
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 30-01-24; Version: 7
//
RX   PubMed=30891005; DOI=10.3389/fmicb.2019.00127;
RA   Tweedell R.E., Tao D.-Y., Hamerly T., Robinson T.M., Larsen S.,
RA   Gronning A.G.B., Norris A.M., King J.G., Law H.C.-H., Baumbach J.,
RA   Bergmann-Leitner E.S., Dinglasan R.R.;
RT   "The selection of a hepatocyte cell line susceptible to Plasmodium
RT   falciparum sporozoite invasion that is associated with expression of
RT   glypican-3.";
RL   Front. Microbiol. 10:127.1-127.16(2019).
//