ID   NALM-6/HDR-C5
AC   CVCL_B7AP
DR   cancercelllines; CVCL_B7AP
DR   Wikidata; Q112129402
RX   PubMed=34823530;
CC   Population: Caucasian.
CC   Characteristics: Made glucocorticoid resistant by culturing the grand-parent cell line under hypoxia for 5 weeks after a single dexamethasone (Dex) treatment (PubMed=34823530).
CC   Sequence variation: Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_B7AN ! NALM-6/HDR
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 30-01-24; Version: 7
//
RX   PubMed=34823530; DOI=10.1186/s12935-021-02335-7; PMCID=PMC8614043;
RA   Li Y.-Y., Zuo C., Gu L.;
RT   "Characterization of a novel glucocorticoid-resistant human B-cell
RT   acute lymphoblastic leukemia cell line, with AMPK, mTOR and fatty acid
RT   synthesis pathway inhibition.";
RL   Cancer Cell Int. 21:623.1-623.14(2021).
//