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Cellosaurus NALM-6/HDR (CVCL_B7AN)

[Text version]
Cell line name NALM-6/HDR
Accession CVCL_B7AN
Resource Identification Initiative To cite this cell line use: NALM-6/HDR (RRID:CVCL_B7AN)
Comments Population: Caucasian.
Characteristics: Made glucocorticoid resistant by culturing the parent cell line under hypoxia for 5 weeks after a single dexamethasone (Dex) treatment (PubMed=31221196; PubMed=34823530).
Doubling time: 19-22 hours (PubMed=34823530).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0092 (NALM-6)
Children:
CVCL_B7AP (NALM-6/HDR-C5)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): PubMed=34823530

Markers:
AmelogeninX,Y
CSF1PO12
D2S44110,14
D3S135816,17
D5S81811,12
D6S104311
D7S8208,10
D13S3178,12
D16S5399,11
FGA22,23
Penta D8,14
Penta E11
TH018,9
TPOX8,10
vWA15

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Publications

PubMed=31221196; DOI=10.1186/s13046-019-1280-2; PMCID=PMC6585113
Gu L., Zhang G., Zhang Y.-L.
A novel method to establish glucocorticoid resistant acute lymphoblastic leukemia cell lines.
J. Exp. Clin. Cancer Res. 38:269.1-269.12(2019)

PubMed=34823530; DOI=10.1186/s12935-021-02335-7; PMCID=PMC8614043
Li Y.-Y., Zuo C., Gu L.
Characterization of a novel glucocorticoid-resistant human B-cell acute lymphoblastic leukemia cell line, with AMPK, mTOR and fatty acid synthesis pathway inhibition.
Cancer Cell Int. 21:623.1-623.14(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7AN
Encyclopedic resources Wikidata; Q112129401
Entry history
Entry creation17-Mar-2022
Last entry update30-Jan-2024
Version number7