ID   CCRF-CEM C7-SC14/HDR
AC   CVCL_B7AI
SY   CEM-C7-SC14/HDR
DR   cancercelllines; CVCL_B7AI
DR   Wikidata; Q111733082
RX   PubMed=31221196;
CC   Population: Caucasian.
CC   Characteristics: Made glucocorticoid resistant by culturing the parent cell line under hypoxia for 5 weeks after a single dexamethasone (Dex) treatment (PubMed=31221196).
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_B7AG ! CCRF-CEM C7-SC14
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 19-12-24; Version: 6
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RX   PubMed=31221196; DOI=10.1186/s13046-019-1280-2; PMCID=PMC6585113;
RA   Gu L., Zhang G., Zhang Y.-L.;
RT   "A novel method to establish glucocorticoid resistant acute
RT   lymphoblastic leukemia cell lines.";
RL   J. Exp. Clin. Cancer Res. 38:269.1-269.12(2019).
//