| Cell line name |
CCRF-CEM C7/HDR-C2 |
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| Synonyms |
CEM-C7/HDR-C2 |
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| Accession |
CVCL_B7AD |
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| Resource Identification Initiative |
To cite this cell line use: CCRF-CEM C7/HDR-C2 (RRID:CVCL_B7AD) |
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| Comments |
Population: Caucasian.
Characteristics: Made glucocorticoid resistant by culturing the grand-parent cell line under hypoxia for 5 weeks after a single dexamethasone (Dex) treatment (PubMed=31221196).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_B7AC (CCRF-CEM C7/HDR) |
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| Sex of cell |
Female |
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| Age at sampling |
3Y11M |
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| Category |
Cancer cell line |
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| Publications | PubMed=31221196; DOI=10.1186/s13046-019-1280-2; PMCID=PMC6585113
Gu L., Zhang G., Zhang Y.-L.
A novel method to establish glucocorticoid resistant acute lymphoblastic leukemia cell lines.
J. Exp. Clin. Cancer Res. 38:269.1-269.12(2019) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_B7AD
|
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| Encyclopedic resources |
Wikidata; Q111733088
|
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| Entry history |
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| Entry creation | 17-Mar-2022 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 6 |
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