ID   CCRF-CEM C7/HDR
AC   CVCL_B7AC
SY   CEM-C7/HDR
DR   cancercelllines; CVCL_B7AC
DR   Wikidata; Q111733087
RX   PubMed=31221196;
CC   Population: Caucasian.
CC   Characteristics: Made glucocorticoid resistant by culturing the parent cell line under hypoxia for 5 weeks after a single dexamethasone (Dex) treatment (PubMed=31221196).
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): PubMed=31221196
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D10S1248: 13,16
ST   D12S391: 18,20
ST   D13S317: 11,12
ST   D16S539: 10,13
ST   D18S51: 13,17
ST   D19S433: 14,15
ST   D21S11: 30,33.2
ST   D2S1338: 24,25
ST   D2S441: 11,14
ST   D3S1358: 15
ST   D5S818: 12,14
ST   D6S1043: 11,14
ST   D7S820: 9,11
ST   D8S1179: 13
ST   FGA: 23
ST   Penta D: 11
ST   Penta E: 5,14
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 17,19
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_B7AA ! CCRF-CEM C7-14
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 19-12-24; Version: 6
//
RX   PubMed=31221196; DOI=10.1186/s13046-019-1280-2; PMCID=PMC6585113;
RA   Gu L., Zhang G., Zhang Y.-L.;
RT   "A novel method to establish glucocorticoid resistant acute
RT   lymphoblastic leukemia cell lines.";
RL   J. Exp. Clin. Cancer Res. 38:269.1-269.12(2019).
//