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Cellosaurus CCRF-CEM C7-14 (CVCL_B7AA)

[Text version]
Cell line name CCRF-CEM C7-14
Synonyms CEM-C7-14
Accession CVCL_B7AA
Resource Identification Initiative To cite this cell line use: CCRF-CEM C7-14 (RRID:CVCL_B7AA)
Comments Population: Caucasian.
Characteristics: Sensitive to glucocorticoid-mediated lysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6825 (CCRF-CEM C7)
Children:
CVCL_B7AG (CCRF-CEM C7-SC14)CVCL_B7AJ (CCRF-CEM-C7-SC2)CVCL_B7AB (CCRF-CEM C7/H)
CVCL_B7AC (CCRF-CEM C7/HDR)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
STR profile Source(s): PubMed=31221196

Markers:
AmelogeninX
CSF1PO11
D2S44111,14
D2S133824,25
D3S135815
D5S81812,13
D6S104311,14
D7S8209,12
D8S117913
D10S124813,14,15
D12S39118,19,20
D13S31711,12
D16S53910,13
D18S5113,17
D19S43314,15
D21S1130,33.2
FGA23
Penta D11
Penta E5,14
TH016,7
TPOX8
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=31221196; DOI=10.1186/s13046-019-1280-2; PMCID=PMC6585113
Gu L., Zhang G., Zhang Y.-L.
A novel method to establish glucocorticoid resistant acute lymphoblastic leukemia cell lines.
J. Exp. Clin. Cancer Res. 38:269.1-269.12(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7AA
Encyclopedic resources Wikidata; Q111733079
Entry history
Entry creation17-Mar-2022
Last entry update19-Dec-2024
Version number6