Cell line name |
CCRF-CEM C1 |
Synonyms |
CCRF/CEM-C1; CEM-C1; CEM C1; CEMC1; CEM clone 1 |
Accession |
CVCL_B7A8 |
Resource Identification Initiative |
To cite this cell line use: CCRF-CEM C1 (RRID:CVCL_B7A8) |
Comments |
Population: Caucasian. Characteristics: Resistant to glucocorticoid-mediated lysis. Doubling time: 25 +- 3 hours (PubMed=6134583). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0207 (CCRF-CEM) Children:
|
Sex of cell |
Female |
Age at sampling |
3Y11M |
Category |
Cancer cell line |
Publications | PubMed=269011 Norman M.R., Thompson E.B. Characterization of a glucocorticoid-sensitive human lymphoid cell line. Cancer Res. 37:3785-3791(1977) PubMed=6134583 Zawydiwski R., Harmon J.M., Thompson E.B. Glucocorticoid-resistant human acute lymphoblastic leukemic cell line with functional receptor. Cancer Res. 43:3865-3873(1983) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_B7A8
|
Encyclopedic resources |
Wikidata; Q111733077
|
Entry history |
Entry creation | 17-Mar-2022 |
Last entry update | 19-Dec-2024 |
Version number | 6 |
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