ID   SW620/Ad300-ABCB1ko
AC   CVCL_B6Y0
DR   cancercelllines; CVCL_B6Y0
DR   Wikidata; Q112041747
RX   PubMed=34977876;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 40; ABCB1.
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_ZZ39 ! SW620/AD300
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 05-10-23; Version: 5
//
RX   PubMed=34977876; DOI=10.1002/mco2.106;
RA   Lei Z.-N., Teng Q.-X., Wu Z.-X., Ping F.-F., Song P., Wurpel J.N.D.,
RA   Chen Z.-S.;
RT   "Overcoming multidrug resistance by knockout of ABCB1 gene using
RT   CRISPR/Cas9 system in SW620/Ad300 colorectal cancer cells.";
RL   MedComm 2:765-777(2021).
//