ID   ACRJ-PC28
AC   CVCL_B6XF
SY   Anti Cancer Research Jamaica-Prostate Cancer 28
DR   ABM; T0398
DR   Wikidata; Q111732869
RX   DOI=10.1158/1538-7755.DISP21-PO-138;
RX   PubMed=36643868;
WW   Info; -; -; https://www.cancer.gov/about-nci/organization/cgh/blog/2021/grantee-spotlight-badal
CC   Population: Caribbean; Jamaican.
CC   Characteristics: Lack of expression of AR (DOI=10.1158/1538-7755.DISP21-PO-138; PubMed=36643868).
CC   Doubling time: 45 hours (DOI=10.1158/1538-7755.DISP21-PO-138; PubMed=36643868).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:1787; CDKN2A.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 10-04-25; Version: 8
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RX   DOI=10.1158/1538-7755.DISP21-PO-138;
RA   Valentine H., Aiken W., Morrison B., Zhao Z.-R., Fowle H.,
RA   Wasserman J.S., Thompson E., Chin W., Young M., Clarke S., Gibbs D.,
RA   Harrison S., McLaughlin W., Kwok T., Jin F., Campbell K.S., Horvath A.,
RA   Thompson R., Lee N.H., Zhou Y., Grana X., Ragin C.C.R.,
RA   Badal-McCreath S.A.M.;
RT   "The first Caribbean cell line, a prostate cancer cell line:
RT   ACRJ-PC28.";
RL   Cancer Epidemiol. Biomarkers Prev. 31 Suppl. 1:PO138-PO138(2022).
//
RX   PubMed=36643868; DOI=10.1158/2767-9764.CRC-22-0245; PMCID=PMC9836004;
RA   Valentine H., Aiken W., Morrison B., Zhao Z.-R., Fowle H.,
RA   Wasserman J.S., Thompson E., Chin W., Young M., Clarke S., Gibbs D.,
RA   Harrison S., McLaughlin W., Kwok T., Jin F., Campbell K.S., Horvath A.,
RA   Thompson R., Lee N.H., Zhou Y., Grana X., Ragin C.C.R.,
RA   Badal-McCreath S.A.M.;
RT   "Expanding the prostate cancer cell line repertoire with ACRJ-PC28, an
RT   AR-negative neuroendocrine cell line derived from an
RT   African-Caribbean patient.";
RL   Cancer Res. Commun. 2:1355-1371(2022).
//