ID   iKLF1.12
AC   CVCL_B6RE
DR   Wikidata; Q111733492
RX   PubMed=30787325;
CC   Characteristics: Using ZFN a CAG-HA-KLF1-ERT2 construct has been inserted at the AAVS1 safe harbor locus so as to allow temporally controlled activation during macrophage differentiation.
CC   Genetic integration: Method=ZFN; Gene=HGNC; 3467; ESR1 (Note=Ligand-binding domain with p.Gly400Val, p.Met543Ala and p.Leu544Ala = ET[T2]).
CC   Genetic integration: Method=ZFN; Gene=HGNC; 6345; KLF1.
CC   Genetic integration: Method=ZFN; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_UL47 ! SFCi55
SX   Female
CA   Induced pluripotent stem cell
DT   Created: 17-03-22; Last updated: 10-09-24; Version: 5
//
RX   PubMed=30787325; DOI=10.1038/s41467-019-08705-0; PMCID=PMC6382809;
RA   Lopez-Yrigoyen M.B., Yang C.-T., Fidanza A., Cassetta L., Taylor A.H.,
RA   McCahill A., Sellink E., von Lindern M., van den Akker E.,
RA   Mountford J.C., Pollard J.W., Forrester L.M.;
RT   "Genetic programming of macrophages generates an in vitro model for
RT   the human erythroid island niche.";
RL   Nat. Commun. 10:881.1-881.11(2019).
//