ID   TJU-UM003
AC   CVCL_B6PX
SY   UM003; Thomas Jefferson University-Uveal Melanoma 003
DR   cancercelllines; CVCL_B6PX
DR   Wikidata; Q112041793
RX   PubMed=24354797;
RX   PubMed=25952648;
CC   Sequence variation: Mutation; HGNC; HGNC:4390; GNAQ; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000375955; Zygosity=Heterozygous (PubMed=24354797; PubMed=25952648).
CC   Derived from site: Metastatic; Retroperitoneal space; UBERON=UBERON_0003693.
DI   NCIt; C7712; Uveal melanoma
DI   ORDO; Orphanet_39044; Uveal melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 19-12-24; Version: 6
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RX   PubMed=24354797; DOI=10.1111/pcmr.12206;
RA   Yoshida M., Selvan S.R., McCue P.A., DeAngelis T., Baserga R., Fujii A.,
RA   Rui H., Mastrangelo M.J., Sato T.;
RT   "Expression of insulin-like growth factor-1 receptor in metastatic
RT   uveal melanoma and implications for potential autocrine and paracrine
RT   tumor cell growth.";
RL   Pigment Cell Melanoma Res. 27:297-308(2014).
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RX   PubMed=25952648; DOI=10.1158/0008-5472.CAN-15-0370; PMCID=PMC4490069;
RA   Cheng H.-Y., Terai M., Kageyama K., Ozaki S., McCue P.A., Sato T.,
RA   Aplin A.E.;
RT   "Paracrine effect of NRG1 and HGF drives resistance to MEK inhibitors
RT   in metastatic uveal melanoma.";
RL   Cancer Res. 75:2737-2748(2015).
//