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Cellosaurus EL4B7-1 (CVCL_B6PG)

[Text version]
Cell line name EL4B7-1
Synonyms EL4-B7-1; B7-1-EL4; B7-EL-4
Accession CVCL_B6PG
Resource Identification Initiative To cite this cell line use: EL4B7-1 (RRID:CVCL_B6PG)
Comments Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:101775; Cd80.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: ChEBI; CHEBI_254496; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene).
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: T-cell; CL=CL_0000084.
Disease Mouse precursor T cell lymphoblastic lymphoma/leukemia (NCIt: C21925)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6N.
Hierarchy Parent: CVCL_0255 (EL4)
Children:
CVCL_B6PI (EL4-B7-1+B7-2)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=7527298
Townsend S.E., Su F.W., Atherton J.M., Allison J.P.
Specificity and longevity of antitumor immune responses induced by B7-transfected tumors.
Cancer Res. 54:6477-6483(1994)

PubMed=10075975; DOI=10.1084/jem.189.6.919; PMCID=PMC2193048
Stremmel C., Greenfield E.A., Howard E., Freeman G.J., Kuchroo V.K.
B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism.
J. Exp. Med. 189:919-930(1999)

PubMed=10477562; DOI=10.4049/jimmunol.163.6.2999
Krummel M.F., Heath W.R., Allison J.
Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: amplification of the lytic potential by B7.
J. Immunol. 163:2999-3006(1999)

Cross-references
Encyclopedic resources Wikidata; Q111733184
Entry history
Entry creation17-Mar-2022
Last entry update19-Dec-2024
Version number7