Cellosaurus cell line NCC-UPS4-C1 (CVCL

Cellosaurus NCC-UPS4-C1 (CVCL_B6KI)

[Text version]

Cell line name

NCC-UPS4-C1

Accession

CVCL_B6KI

Resource Identification Initiative

To cite this cell line use: NCC-UPS4-C1 (RRID:CVCL_B6KI)

Comments

Part of: NCC sarcoma cell line panel.
Population: Japanese.
Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo T.).
Doubling time: 76 hours (PubMed=35118583).
Omics: SNP array analysis.
Derived from site: Metastatic; Right knee, hypodermis; UBERON=UBERON_0001465+UBERON_0002072.

Sequence variations

Mutation; HGNC; 11998; TP53; Simple; p.Glu286Lys (c.856G>A); ClinVar=VCV000183752; Zygosity=Heterozygous (PubMed=35118583).
Mutation; HGNC; 11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Heterozygous (PubMed=35118583).

Disease

Li-Fraumeni syndrome (NCIt: C3476)
Undifferentiated pleomorphic sarcoma (NCIt: C4247)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Undifferentiated pleomorphic sarcoma (ORDO: Orphanet_2023)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

32Y

Category

Cancer cell line

STR profile

Source(s): PubMed=35118583

Markers:

Amelogenin	X
CSF1PO	11,12
D5S818	10,11
D7S820	11
D13S317	9,13
D16S539	12
D21S11	29,32.2
TH01	7,8
TPOX	8,9
vWA	14,19

Web pages

https://en.cellline.jp/product/ncc-ups4-c1/

Publications

PubMed=35118583; DOI=10.1007/s13577-022-00671-y
Ono T., Yoshimatsu Y., Noguchi R., Sin Y., Tsuchiya R., Akiyama T., Sugaya J., Fukushima S., Kojima N., Yoshida A., Kawai A., Kondo T.
Establishment and characterization of NCC-UPS4-C1: a novel cell line of undifferentiated pleomorphic sarcoma from a patient with Li-Fraumeni syndrome.
Hum. Cell 35:756-766(2022)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_B6KI

Encyclopedic resources

Wikidata; Q112129416

Entry history

Entry creation

17-Mar-2022

Last entry update

30-Jan-2024

Version number