ID   mEERL
AC   CVCL_B6J3
SY   mouse E6 E7 Ras Luc; E6/E7/H-ras/Luc MTEC
DR   ABM; T8309
DR   GEO; GSM1687302
DR   GEO; GSM1687303
DR   GEO; GSM1687304
DR   Wikidata; Q112129252
RX   PubMed=17515506;
RX   PubMed=19283850;
RX   PubMed=27013584;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: Transcriptome analysis by microarray.
CC   Miscellaneous: Age/sex of donor from personal communication of Vermeer, Paola D.
CC   Caution: Was originally said to be derived from tonsils, an anatomical structure that does not exist in mouse.
CC   Derived from site: In situ; Pharynx, oropharynx; UBERON=UBERON_0001729.
CC   Cell type: Epithelial cell; CL=CL_0000066.
CC   Breed/subspecies: C57BL/6.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_B6J2 ! mEER
SX   Male
AG   6-8W
CA   Transformed cell line
DT   Created: 17-03-22; Last updated: 19-12-24; Version: 7
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RX   PubMed=17515506; DOI=10.1001/archotol.133.5.495; PMCID=PMC2917346;
RA   Hoover A.C., Spanos W.C., Harris G.F., Anderson M.E.,
RA   Klingelhutz A.J., Lee J.H.;
RT   "The role of human papillomavirus 16 E6 in anchorage-independent and
RT   invasive growth of mouse tonsil epithelium.";
RL   Arch. Otolaryngol. Head Neck Surg. 133:495-502(2007).
//
RX   PubMed=19283850; DOI=10.1002/hed.21040;
RA   Williams R., Lee D.W., Elzey B.D., Anderson M.E., Hostager B.S.,
RA   Lee J.H.;
RT   "Preclinical models of HPV+ and HPV- HNSCC in mice: an immune
RT   clearance of HPV+ HNSCC.";
RL   Head Neck 31:911-918(2009).
//
RX   PubMed=27013584; DOI=10.18632/oncotarget.8254; PMCID=PMC5029694;
RA   Vermeer D.W., Coppock J.D., Zeng E.-L., Lee K.M., Spanos W.C.,
RA   Onken M.D., Uppaluri R., Lee J.H., Vermeer P.D.;
RT   "Metastatic model of HPV+ oropharyngeal squamous cell carcinoma
RT   demonstrates heterogeneity in tumor metastasis.";
RL   Oncotarget 7:24194-24207(2016).
//