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Cellosaurus mEER (CVCL_B6J2)

[Text version]
Cell line name mEER
Synonyms mouse E6 E7 Ras; E6/E7/H-ras MTEC
Accession CVCL_B6J2
Resource Identification Initiative To cite this cell line use: mEER (RRID:CVCL_B6J2)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Miscellaneous: Age/sex of donor from personal communication of Vermeer, Paola D.
Caution: Was originally said to be derived from tonsils, an anatomical structure that does not exist in mouse.
Derived from site: In situ; Pharynx, oropharynx; UBERON=UBERON_0001729.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Children:
CVCL_B6J3 (mEERL)
Sex of cell Male
Age at sampling 6-8W
Category Transformed cell line
Publications

PubMed=17515506; DOI=10.1001/archotol.133.5.495; PMCID=PMC2917346
Hoover A.C., Spanos W.C., Harris G.F., Anderson M.E., Klingelhutz A.J., Lee J.H.
The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium.
Arch. Otolaryngol. Head Neck Surg. 133:495-502(2007)

PubMed=19283850; DOI=10.1002/hed.21040
Williams R., Lee D.W., Elzey B.D., Anderson M.E., Hostager B.S., Lee J.H.
Preclinical models of HPV+ and HPV- HNSCC in mice: an immune clearance of HPV+ HNSCC.
Head Neck 31:911-918(2009)

PubMed=27013584; DOI=10.18632/oncotarget.8254; PMCID=PMC5029694
Vermeer D.W., Coppock J.D., Zeng E.-L., Lee K.M., Spanos W.C., Onken M.D., Uppaluri R., Lee J.H., Vermeer P.D.
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis.
Oncotarget 7:24194-24207(2016)

Cross-references
Encyclopedic resources Wikidata; Q112129251
Entry history
Entry creation17-Mar-2022
Last entry update10-Apr-2025
Version number8