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Cellosaurus IM-9-P (CVCL_B6CV)

[Text version]
Cell line name IM-9-P
Accession CVCL_B6CV
Resource Identification Initiative To cite this cell line use: IM-9-P (RRID:CVCL_B6CV)
Comments Problematic cell line: Misclassified. Parent cell line originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line.
Population: Caucasian.
Characteristics: Produces prolactin. But after approximately 7 months in culture the capacity to synthesize prolactin is greatly reduced (PubMed=1366653; PubMed=2836165).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1305 (IM-9)
Children:
CVCL_B6CW (IM-9-P3)CVCL_B6CX (IM-9-P6)
Sex of cell Female
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=2836165; DOI=10.1210/endo-122-6-2508
DiMattia G.E., Gellersen B., Bohnet H.G., Friesen H.G.
A human B-lymphoblastoid cell line produces prolactin.
Endocrinology 122:2508-2517(1988)

PubMed=1366653; DOI=10.1007/BF00365265
Bonhoff A., Gellersen B., Held K.R., Bohnet H.G.
Clonal derivatives of a human B-lymphoblastoid cell line producing prolactin -- a cytogenetic characterization.
Cytotechnology 3:43-50(1990)

PubMed=1697858; DOI=10.1016/S0021-9258(17)46238-7
DiMattia G.E., Gellersen B., Duckworth M.L., Friesen H.G.
Human prolactin gene expression. The use of an alternative noncoding exon in decidua and the IM-9-P3 lymphoblast cell line.
J. Biol. Chem. 265:16412-16421(1990)

Cross-references
Encyclopedic resources Wikidata; Q111733497
Entry history
Entry creation17-Mar-2022
Last entry update19-Dec-2024
Version number5