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Cellosaurus HepaRG 5F (CVCL_B6A6)

[Text version]
Cell line name HepaRG 5F
Synonyms HepaRG 5F Control Cells
Accession CVCL_B6A6
Resource Identification Initiative To cite this cell line use: HepaRG 5F (RRID:CVCL_B6A6)
Comments Characteristics: These cells were modified with the use of transfected mRNA encoding ZFNs targeting a specific site (Sigma-Aldrich=MTOX1010).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Hepatitis C infection (NCIt: C3098)
Hepatocellular carcinoma (NCIt: C3099)
Hepatocellular carcinoma (ORDO: Orphanet_88673)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9720 (HepaRG)
Children:
CVCL_B6A7 (HepaRG AHR KO)CVCL_B6A8 (HepaRG BCRP KO)CVCL_B6A9 (HepaRG BSEP KO)
CVCL_B6AA (HepaRG CAR KO)CVCL_B6AB (HepaRG CYP3A4 KO)CVCL_B6AC (HepaRG FXR KO)
CVCL_B6AD (HepaRG MATE1 KO)CVCL_B6AE (HepaRG MDR1 KO)CVCL_B6AF (HepaRG MDR3 KO)
CVCL_B6AG (HepaRG MRP2 KO)CVCL_B6AH (HepaRG MRP2/MRP4 KO)CVCL_B6AI (HepaRG MRP3 KO)
CVCL_B6AJ (HepaRG MRP4 KO)CVCL_B6AK (HepaRG MRP6 KO)CVCL_B6AL (HepaRG OATP1B1 KO)
CVCL_B6AM (HepaRG OATP1B1/OATP1B3 KO)CVCL_B6AN (HepaRG OATP1B3 KO)CVCL_B6AP (HepaRG P66SHC KO)
CVCL_B6AQ (HepaRG PERK KO)CVCL_B6AR (HepaRG POR KO)CVCL_B6AS (HepaRG PXR KO)
CVCL_B6AT (HepaRG PXR/CAR KO)CVCL_B6AU (HepaRG SOD2 KO)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=27713827; DOI=10.1002/prp2.264; PMCID=PMC5045942
Williamson B., Lorbeer M., Mitchell M.D., Brayman T.G., Riley R.J.
Evaluation of a novel PXR-knockout in HepaRG(TM) cells.
Pharmacol. Res. Perspect. 4:e00264.1-e00264.11(2016)

Cross-references
Cell line collections (Providers) Sigma-Aldrich; MTOX1010
Encyclopedic resources Wikidata; Q111733354
Entry history
Entry creation17-Mar-2022
Last entry update10-Sep-2024
Version number6