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Cellosaurus Hepc/3A4.2-30 (CVCL_B5W4)

[Text version]
Cell line name Hepc/3A4.2-30
Accession CVCL_B5W4
Resource Identification Initiative To cite this cell line use: Hepc/3A4.2-30 (RRID:CVCL_B5W4)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2637; CYP3A4.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=11377097; DOI=10.1016/S0887-2333(01)00011-x
Yoshitomi S., Ikemoto K., Takahashi J., Miki H., Namba M., Asahi S.
Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology.
Toxicol. In Vitro 15:245-256(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B5W4
Encyclopedic resources Wikidata; Q111733391
Entry history
Entry creation17-Mar-2022
Last entry update10-Sep-2024
Version number6