ID   OCUT-1F
AC   CVCL_B5GF
SY   Osaka City University Thyroid-1F
DR   cancercelllines; CVCL_B5GF
DR   JCRB; JCRB1897
DR   Wikidata; Q110433123
RX   PubMed=24357248;
RX   PubMed=26137260;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=24357248).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Homozygous; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): JCRB=JCRB1897
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D13S317: 8
ST   D16S539: 10,12
ST   D5S818: 9,13
ST   D7S820: 11,13
ST   TH01: 6,9
ST   TPOX: 8,11
ST   vWA: 16,18
DI   NCIt; C3878; Thyroid gland anaplastic carcinoma
DI   ORDO; Orphanet_142; Anaplastic thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6017 ! OCUT-1
SX   Female
AG   74Y
CA   Cancer cell line
DT   Created: 16-12-21; Last updated: 19-12-24; Version: 7
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RX   PubMed=24357248; DOI=10.1007/s00268-013-2409-7;
RA   Onoda N., Nakamura M., Aomatsu N., Noda S., Kashiwagi S., Hirakawa K.;
RT   "Establishment, characterization and comparison of seven authentic
RT   anaplastic thyroid cancer cell lines retaining clinical features of
RT   the original tumors.";
RL   World J. Surg. 38:688-695(2014).
//
RX   PubMed=26137260; DOI=10.3892/mco.2015.496; PMCID=PMC4471583;
RA   Onoda N., Nakamura M., Aomatsu N., Noda S., Kashiwagi S., Kurata K.,
RA   Uchino S., Hirakawa K.;
RT   "Significant cytostatic effect of everolimus on a gefitinib-resistant
RT   anaplastic thyroid cancer cell line harboring PI3KCA gene mutation.";
RL   Mol. Clin. Oncol. 3:522-526(2015).
//