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Cellosaurus K562 BZQR (CVCL_B502)

[Text version]
Cell line name K562 BZQR
Synonyms K562BZQR; BZQR
Accession CVCL_B502
Resource Identification Initiative To cite this cell line use: K562 BZQR (RRID:CVCL_B502)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:90193; NSC-224070 (BZQ; 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX
D8S117912
D18S5116
D21S1129,30
FGA21,24
TH019.3
vWA16

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Publications

PubMed=7646550; DOI=10.1016/0006-2952(95)00155-S
Ward T.H., Haran M.S., Whittaker D., Watson A.J., Howard T.D., Butler J.
Cross-resistance studies on two K562 sublines resistant to diaziridinylbenzoquinones.
Biochem. Pharmacol. 50:459-464(1995)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

Cross-references
Encyclopedic resources Wikidata; Q54899292
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number22