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Cellosaurus Twin-N (CVCL_B4L2)

[Text version]
Cell line name Twin-N
Synonyms T2N
Accession CVCL_B4L2
Resource Identification Initiative To cite this cell line use: Twin-N (RRID:CVCL_B4L2)
Comments From: University of Geneva; Geneva; Switzerland.
Population: Caucasian.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: Deep proteome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Omics: Transcriptome analysis by single cell RNAseq.
Donor information: Twin-DS (Cellosaurus=CVCL_B4L1) and Twin-N originate from monozygotic twins discordant for trisomy 21.
Derived from site: In situ; Forearm, skin; UBERON=UBERON_0003403.
Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B4L3 (Twin-N-iPSCs line#7)CVCL_W087 (Twin-N-iPSCs line#8)
Sex of cell Female
Age at sampling 16FW
Category Finite cell line
Publications

PubMed=24375627; DOI=10.1002/emmm.201302848; PMCID=PMC3927959
Hibaoui Y., Grad I., Letourneau A., Sailani M.R., Dahoun S., Santoni F.A., Gimelli S., Guipponi M., Pelte M.-F., Sloan-Bena F., Antonarakis S.E., Feki A.
Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21.
EMBO Mol. Med. 6:259-277(2014)

PubMed=24740065; DOI=10.1038/nature13200
Letourneau A., Santoni F.A., Bonilla X., Sailani M.R., Gonzalez D., Kind J., Chevalier C., Thurman R., Sandstrom R.S., Hibaoui Y., Garieri M., Popadin K.Y., Falconnet E., Gagnebin M., Gehrig C., Vannier A., Guipponi M., Farinelli L., Robyr D., Migliavacca E., Borel C., Deutsch S., Feki A., Stamatoyannopoulos J.A., Herault Y., van Steensel B., Guigo R., Antonarakis S.E.
Domains of genome-wide gene expression dysregulation in Down's syndrome.
Nature 508:345-350(2014)

PubMed=25557783; DOI=10.1016/j.ajhg.2014.12.001; PMCID=PMC4289680
Borel C., Ferreira P.G., Santoni F.A., Delaneau O., Fort A., Popadin K.Y., Garieri M., Falconnet E., Ribaux P., Guipponi M., Padioleau I., Carninci P., Dermitzakis E.T., Antonarakis S.E.
Biased allelic expression in human primary fibroblast single cells.
Am. J. Hum. Genet. 96:70-80(2015)

PubMed=28190458; DOI=10.1016/j.ajhg.2017.01.028; PMCID=PMC5339288
Santoni F.A., Stamoulis G., Garieri M., Falconnet E., Ribaux P., Borel C., Antonarakis S.E.
Detection of imprinted genes by single-cell allele-specific gene expression.
Am. J. Hum. Genet. 100:444-453(2017)

PubMed=30510006; DOI=10.1073/pnas.1806811115; PMCID=PMC6304968
Garieri M., Stamoulis G., Blanc X., Falconnet E., Ribaux P., Borel C., Santoni F.A., Antonarakis S.E.
Extensive cellular heterogeneity of X inactivation revealed by single-cell allele-specific expression in human fibroblasts.
Proc. Natl. Acad. Sci. U.S.A. 115:13015-13020(2018)

PubMed=32739879; DOI=10.1016/j.scr.2020.101920
Feki A., Sloan-Bena F., Hibaoui Y.
Parallel derivation of X-monosomy induced pluripotent stem cells (iPSCs) with isogenic control iPSCs.
Stem Cell Res. 47:101920-101920(2020)

Cross-references
Encyclopedic resources Wikidata; Q110433294
Gene expression databases GEO; GSE123028
GEO; GSE135500
GEO; GSM1338309
GEO; GSM1338310
GEO; GSM1338344
GEO; GSM1338342
GEO; GSM1338312
GEO; GSM1338314
GEO; GSM1338316
GEO; GSM1338318
GEO; GSM1333658
GEO; GSM1333660
Proteomic databases PRIDE; PXD004880
Entry history
Entry creation16-Dec-2021
Last entry update10-Sep-2024
Version number6