ID   iChEC-1
AC   CVCL_B4IK
SY   immortalized Choroidal Endothelial Cell-1
DR   Wikidata; Q110432916
RX   PubMed=30571950;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:4883; CFH; Simple; p.Val62Ile (c.184G>A); ClinVar=VCV000016550; Zygosity=Homozygous (PubMed=30571950).
CC   Sequence variation: Mutation; HGNC; HGNC:13941; SLC44A4; Simple; p.Asp123Val (c.368A>T); dbSNP=rs12661281; Zygosity=Homozygous (PubMed=30571950).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Eye, choroid; UBERON=UBERON_0001776.
CC   Cell type: Endothelial cell; CL=CL_0000115.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   1M
CA   Transformed cell line
DT   Created: 16-12-21; Last updated: 10-04-25; Version: 7
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RX   PubMed=30571950; DOI=10.1016/j.mvr.2018.12.002; PMCID=PMC7401191;
RA   Giacalone J.C., Miller M.J., Workalemahu G., Reutzel A.J., Ochoa D.,
RA   Whitmore S.S., Stone E.M., Tucker B.A., Mullins R.F.;
RT   "Generation of an immortalized human choroid endothelial cell line
RT   (iChEC-1) using an endothelial cell specific promoter.";
RL   Microvasc. Res. 123:50-57(2019).
//