ID   IW32
AC   CVCL_B4H1
SY   IW.32
DR   Wikidata; Q110432993
RX   Patent=FR2550216A1;
RX   PubMed=2355917;
RX   PubMed=2735652;
RX   PubMed=2766927;
RX   PubMed=3561395;
RX   PubMed=3861324;
RX   PubMed=6578507;
RX   PubMed=6589018;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-234.
CC   Characteristics: Constitutively synthesizes and secretes erythropoietin (PubMed=6578507; PubMed=6589018).
CC   Characteristics: One of the two copies of the EPO locus has undergone rearrangement and amplification (PubMed=2766927; PubMed=3561395).
CC   Transformant: NCBI_TaxID; 11795; Friend murine leukemia virus (FrMLV).
CC   Breed/subspecies: ICFW.
DI   NCIt; C21895; Mouse erythroid leukemia
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
CA   Cancer cell line
DT   Created: 16-12-21; Last updated: 21-03-23; Version: 3
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RX   Patent=FR2550216A1;
RA   Levy J.-P., Varet B.;
RT   "New cell line, its production and its application in the preparation
RT   of a factor having erythropoietic activity.";
RL   Patent number FR2550216A1, 08-Feb-1985.
//
RX   PubMed=2355917; DOI=10.1128/mcb.10.7.3591-3595.1990;
RA   Beru N., Maples P.B., Hermine O., Goldwasser E.;
RT   "Differential expression of alpha- and beta-globin genes in
RT   erythroleukemic cell lines.";
RL   Mol. Cell. Biol. 10:3591-3595(1990).
//
RX   PubMed=2735652; DOI=10.1111/j.1749-6632.1989.tb22406.x;
RA   Beru N., McDonald J., Goldwasser E.;
RT   "Studies of the constitutive expression of the mouse erythropoietin
RT   gene.";
RL   Ann. N. Y. Acad. Sci. 554:29-35(1989).
//
RX   PubMed=2766927; DOI=10.1089/dna.1.1989.8.253;
RA   Beru N., McDonald J., Goldwasser E.;
RT   "Activation of the erythropoietin gene due to the proximity of an
RT   expressed gene.";
RL   DNA 8:253-259(1989).
//
RX   PubMed=3561395; DOI=10.1128/mcb.7.1.365-370.1987;
RA   McDonald J., Beru N., Goldwasser E.;
RT   "Rearrangement and expression of erythropoietin genes in transformed
RT   mouse cells.";
RL   Mol. Cell. Biol. 7:365-370(1987).
//
RX   PubMed=3861324;
RA   Choppin J., Casadevall N., Lacombe C., Wendling F., Goldwasser E.,
RA   Berger R., Tambourin P., Varet B.;
RT   "Production of erythropoietin by cloned malignant murine erythroid
RT   cells.";
RL   Exp. Hematol. 13:610-615(1985).
//
RX   PubMed=6578507; DOI=10.1073/pnas.80.20.6269;
RA   Tambourin P., Casadevall N., Choppin J., Lacombe C., Heard J.M.,
RA   Fichelson S., Wendling F., Hankins W.D., Varet B.;
RT   "Production of erythropoietin-like activity by a murine
RT   erythroleukemia cell line.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:6269-6273(1983).
//
RX   PubMed=6589018; DOI=10.1182/blood.V64.2.341.341;
RA   Choppin J., Lacombe C., Casadevall N., Muller O., Tambourin P.,
RA   Varet B.;
RT   "Characterization of erythropoietin produced by IW32 murine
RT   erythroleukemia cells.";
RL   Blood 64:341-347(1984).
//