ID   YULAC
AC   CVCL_B483
DR   cancercelllines; CVCL_B483
DR   Cosmic; 1197390
DR   Cosmic; 1548864
DR   Wikidata; Q54995676
RX   PubMed=20149136;
RX   PubMed=21521745;
RX   PubMed=21543894;
RX   PubMed=21569352;
RX   PubMed=22842228;
RX   PubMed=23012583;
CC   Part of: Yale University (YU) melanoma cell collection.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Lys (c.1798_1799delGTinsAA); ClinVar=VCV000375941; Zygosity=Heterozygous (PubMed=20149136).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Neck, hypodermis; UBERON=UBERON_0000974+UBERON_0002072.
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   65Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 20
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RX   PubMed=20149136; DOI=10.1111/j.1755-148X.2010.00685.x;
RA   Halaban R., Zhang W., Bacchiocchi A., Cheng E., Parisi F., Ariyan S.,
RA   Krauthammer M., McCusker J.P., Kluger Y., Sznol M.;
RT   "PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK
RT   pathway and enhances cell migration and proliferation of BRAF melanoma
RT   cells.";
RL   Pigment Cell Melanoma Res. 23:190-200(2010).
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RX   PubMed=21521745; DOI=10.1158/1541-7786.MCR-10-0512;
RA   Tworkoski K., Singhal G., Szpakowski S., Zito C.I., Bacchiocchi A.,
RA   Muthusamy V., Bosenberg M.W., Krauthammer M., Halaban R., Stern D.F.;
RT   "Phosphoproteomic screen identifies potential therapeutic targets in
RT   melanoma.";
RL   Mol. Cancer Res. 9:801-812(2011).
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RX   PubMed=21543894; DOI=10.4161/cc.10.11.15777;
RA   Chan E., Patel R., Nallur S., Ratner E., Bacchiocchi A., Hoyt K.,
RA   Szpakowski S., Godshalk S., Ariyan S., Sznol M., Halaban R.,
RA   Krauthammer M., Tuck D., Slack F.J., Weidhaas J.B.;
RT   "MicroRNA signatures differentiate melanoma subtypes.";
RL   Cell Cycle 10:1845-1852(2011).
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RX   PubMed=21569352; DOI=10.1186/1471-2164-12-230;
RA   Parisi F., Ariyan S., Narayan D., Bacchiocchi A., Hoyt K., Cheng E.,
RA   Xu F., Li P.-N., Halaban R., Kluger Y.;
RT   "Detecting copy number status and uncovering subclonal markers in
RT   heterogeneous tumor biopsies.";
RL   BMC Genomics 12:230.1-230.14(2011).
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RX   PubMed=22842228; DOI=10.1038/ng.2359;
RA   Krauthammer M., Kong Y., Ha B.H., Evans P., Bacchiocchi A.,
RA   McCusker J.P., Cheng E., Davis M.J., Goh G., Choi M., Ariyan S.,
RA   Narayan D., Dutton-Regester K., Capatana A., Holman E.C.,
RA   Bosenberg M.W., Sznol M., Kluger H.M., Brash D.E., Stern D.F.,
RA   Materin M.A., Lo R.S., Mane S., Ma S.-G., Kidd K.K., Hayward N.K.,
RA   Lifton R.P., Schlessinger J., Boggon T.J., Halaban R.;
RT   "Exome sequencing identifies recurrent somatic RAC1 mutations in
RT   melanoma.";
RL   Nat. Genet. 44:1006-1014(2012).
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RX   PubMed=23012583;
RA   Parisi F., Micsinai M., Strino F., Ariyan S., Narayan D.,
RA   Bacchiocchi A., Cheng E., Xu F., Li P.-N., Kluger H.M., Halaban R.,
RA   Kluger Y.;
RT   "Integrated analysis of tumor samples sheds light on tumor
RT   heterogeneity.";
RL   Yale J. Biol. Med. 85:347-361(2012).
//