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Cellosaurus TR14 (CVCL_B474)

[Text version]
Cell line name TR14
Synonyms TR-14
Accession CVCL_B474
Resource Identification Initiative To cite this cell line use: TR14 (RRID:CVCL_B474)
Comments Doubling time: 3 days (PubMed=6861117).
Omics: Single-cell extrachromosomal circular DNA and transcriptome sequencing (scEC&Tseq).
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by single cell RNAseq.
Miscellaneous: STR profile from personal communication of Henssen, Anton George and Roefzaad, Claudia.
Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
Disease Adrenal gland neuroblastoma (NCIt: C4827)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 3Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO10,11,12,13
D2S133818,23
D3S135817
D5S81811,12,13,14
D7S82010,11,12
D8S117914,15,16,17
D13S31710,11
D16S53910,11,12
D18S5112,15,16
D19S43312,13
D21S1128,29,30,31,32
FGA19,20,21,22
TH016,7
TPOX9,11,12
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=6861117; DOI=10.1016/0165-4608(83)90011-0
Cowell J.K., Rupniak H.T.
Chromosome analysis of human neuroblastoma cell line TR14 showing double minutes and an aberration involving chromosome 1.
Cancer Genet. Cytogenet. 9:273-280(1983)

PubMed=6144383
Rupniak H.T., Rein G., Powell J.F., Ryder T.A., Carson S., Povey S., Hill B.T.
Characteristics of a new human neuroblastoma cell line which differentiates in response to cyclic adenosine 3':5'-monophosphate.
Cancer Res. 44:2600-2607(1984)

PubMed=7838528
Cheng N.C., Van Roy N., Chan A., Beitsma M., Westerveld A., Speleman F., Versteeg R.
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)

PubMed=9283597; DOI=10.1016/S0165-4608(96)00362-7
Van Roy N., Jauch A., Van Gele M., Laureys G., Versteeg R., De Paepe A., Cremer T., Speleman F.
Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.
Cancer Genet. Cytogenet. 97:135-142(1997)

PubMed=9516836; DOI=10.1016/S0959-8049(97)00319-5
Van Roy N., Laureys G., Van Gele M., Opdenakker G., Miura R., van der Drift P., Chan A., Versteeg R., Speleman F.
Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes.
Eur. J. Cancer 33:1974-1978(1997)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027
Holzel M., Huang S.-D., Koster J., Ora I., Lakeman A., Caron H.N., Nijkamp W., Xie J., Callens T., Asgharzadeh S., Seeger R.C., Messiaen L.M., Versteeg R., Bernards R.
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=39255063; DOI=10.1016/j.celrep.2024.114711
Stober M.-C., Chamorro Gonzalez R., Bruckner L., Conrad T., Wittstruck N., Krienelke Szymansky A., Eggert A., Schulte J.H., Koche R.P., Henssen A.G., Schwarz R.F., Haase K.
Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity.
Cell Rep. 43:114711.1-114711.19(2024)

Cross-references
Encyclopedic resources Wikidata; Q54972929
Gene expression databases GEO; GSM692868
Polymorphism and mutation databases Cosmic; 1109113
Cosmic; 1518080
Cosmic; 1526657
Cosmic; 2239466
IARC_TP53; 23836
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number13