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Cellosaurus OHS (CVCL_B450)

[Text version]
Cell line name OHS
Synonyms OHSX; OHS/X; OHS-50; OHS-50T
Accession CVCL_B450
Resource Identification Initiative To cite this cell line use: OHS (RRID:CVCL_B450)
Comments Population: Caucasian.
Doubling time: ~36 hours (PubMed=21519327).
Omics: SNP array analysis.
Derived from site: In situ; Bone, distal femur; UBERON=UBERON_0004406.
Sequence variations
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_R724 (OHS-4)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792

Markers:
AmelogeninX
D2S133824,25
D3S135816,19
D5S81810
D8S117913
D16S53912
D18S5112,14
D19S43314,15
D21S1130
FGA20,22
SE3326.2
TH019
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=3459716; DOI=10.1002/ijc.2910380107
Fodstad O., Brogger A., Bruland O.S., Solheim O.P., Nesland J.M., Pihl A.
Characteristics of a cell line established from a patient with multiple osteosarcoma, appearing 13 years after treatment for bilateral retinoblastoma.
Int. J. Cancer 38:33-40(1986)

PubMed=2233717; DOI=10.1128/mcb.10.11.5772-5781.1990; PMCID=PMC361354
Diller L., Kassel J., Nelson C.E., Gryka M.A., Litwak G., Gebhardt M., Bressac B., Ozturk M., Baker S.J., Vogelstein B., Friend S.H.
p53 functions as a cell cycle control protein in osteosarcomas.
Mol. Cell. Biol. 10:5772-5781(1990)

PubMed=8198963; DOI=10.1038/bjc.1994.200; PMCID=PMC1969443
Kjonniksen I., Rye P.D., Fodstad O.
Helix pomatia agglutinin binding in human tumour cell lines: correlation with pulmonary metastases in nude mice.
Br. J. Cancer 69:1021-1024(1994)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21519327; DOI=10.1038/labinvest.2011.72
Mohseny A.B., Machado I., Cai Y.-P., Schaefer K.-L., Serra M., Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
Lab. Invest. 91:1195-1205(2011)

PubMed=23144859; DOI=10.1371/journal.pone.0048262; PMCID=PMC3492335
Kresse S.H., Rydbeck H., Skarn M., Namlos H.M., Barragan-Polania A.H., Cleton-Jansen A.-M., Serra M., Liestol K., Hogendoorn P.C.W., Hovig E., Myklebost O., Meza-Zepeda L.A.
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma.
PLoS ONE 7:E48262-E48262(2012)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B450
Encyclopedic resources Wikidata; Q38098672
Gene expression databases GEO; GSM879220
GEO; GSM1676308
GEO; GSM1701642
Polymorphism and mutation databases Cosmic; 1529909
IARC_TP53; 2149
Progenetix; CVCL_B450
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number16