ID   MBU-8
AC   CVCL_B3XV
DR   cancercelllines; CVCL_B3XV
DR   DSMZ; ACC-910
DR   DSMZCellDive; ACC-910
DR   Wikidata; Q110433018
RX   PubMed=34707142;
CC   Population: Caucasian.
CC   Doubling time: 30-40 hours (Direct_author_submission); ~30 hours (DSMZ=ACC-910).
CC   Karyotypic information: Compared to the parent cell line, has a complete trisomy of chromosome 18 as well as a partial trisomy of 7 and tetrasomy of 8p (PubMed=34707142).
CC   Sequence variation: Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (PubMed=34707142).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (PubMed=34707142).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=34707142).
CC   Sequence variation: Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (PubMed=34707142).
CC   Miscellaneous: Doubling time from personal communication of Diesch J.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): DSMZ; PubMed=34707142
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10,12
ST   D16S539: 12
ST   D18S51: 13,14
ST   D19S433: 14,16
ST   D21S11: 27,29
ST   D2S1338: 17,20
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 9,11
ST   D8S1179: 12,13
ST   FGA: 22,25
ST   Penta D: 12,13
ST   Penta E: 13
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 14,15
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 16-12-21; Last updated: 05-10-23; Version: 7
//
RX   PubMed=34707142; DOI=10.1038/s41598-021-00623-w;
RA   Maher M., Diesch J., Le Pannerer M.-M., Cabezon M., Mallo M.,
RA   Vergara S., Mendez Lopez A., Mesa Tudel A., Sole F., Sorigue M.,
RA   Zamora L., Granada I., Buschbeck M.;
RT   "Divergent leukaemia subclones as cellular models for testing
RT   vulnerabilities associated with gains in chromosomes 7, 8 or 18.";
RL   Sci. Rep. 11:21145-21145(2021).
//