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Cellosaurus MBU-7 (CVCL_B3XU)

[Text version]
Cell line name MBU-7
Accession CVCL_B3XU
Resource Identification Initiative To cite this cell line use: MBU-7 (RRID:CVCL_B3XU)
Comments Population: Caucasian.
Doubling time: 30-40 hours (Direct_author_submission); ~48 hours (DSMZ=ACC-909).
Karyotypic information: Compared to the parent cell line, has a complete trisomy of chromosome 7 (PubMed=34707142).
Miscellaneous: Doubling time from personal communication of Diesch, Jeannine.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (PubMed=34707142).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (PubMed=34707142).
  • Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=34707142).
  • Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (PubMed=34707142).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): PubMed=34707142

Markers:
AmelogeninX
CSF1PO12
D2S133817,20
D3S135816
D5S81812
D7S8209,11
D8S117912,13
D13S31710,12
D16S53912
D18S5113,14
D19S43314,16
D21S1127,29
FGA22,25
TH016,9.3
TPOX8,11
vWA14,15

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Publications

PubMed=34707142; DOI=10.1038/s41598-021-00623-w; PMCID=PMC8551338
Maher M., Diesch J., Le Pannerer M.-M., Cabezon M., Mallo M., Vergara S., Mendez Lopez A., Mesa Tudel A., Sole F., Sorigue M., Zamora L., Granada I., Buschbeck M.
Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18.
Sci. Rep. 11:21145-21145(2021)

Cross-references
Cell line collections (Providers) DSMZ; ACC-909
Cell line databases/resources cancercelllines; CVCL_B3XU
DSMZCellDive; ACC-909
Encyclopedic resources Wikidata; Q110433017
Entry history
Entry creation16-Dec-2021
Last entry update10-Sep-2024
Version number8