ID   IV-A1-j
AC   CVCL_B3UN
SY   IV-AI-j; A1-j
DR   Wikidata; Q110432990
RX   CelloPub=CLPUB00663;
RX   CelloPub=CLPUB00664;
RX   PubMed=1369208;
RX   PubMed=8468364;
CC   Characteristics: Resistant to an insulin-diphtheria-A chain toxic conjugate (DTaI).
CC   Selected for resistance to: Diphtheria A chain:insulin (DTaI).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_2234 ! V79
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 16-12-21; Last updated: 05-10-23; Version: 5
//
RX   CelloPub=CLPUB00663;
RA   Leckett B.;
RT   "The selection, isolation, and characterization of a Chinese hamster
RT   lung fibroblast cell line resistant to an insulin-diphteria A-chain
RT   toxic conjugate molecule.";
RL   Thesis PhD (1992); McGill University Montreal; Montreal; Canada.
//
RX   CelloPub=CLPUB00664;
RA   Spurmanis A.;
RT   "Characterization of a mutant Chinese hamster fibroblast line
RT   resistant to the mitogenic effects of insulin.";
RL   Thesis MSc (1996); Concordia University; Montreal; Canada.
//
RX   PubMed=1369208; DOI=10.1007/BF00570889;
RA   Leckett B., Germinario R.J.;
RT   "Construction of a toxic insulin molecule: selection and partial
RT   characterization of cells resistant to its killing effects.";
RL   Cytotechnology 10:125-136(1992).
//
RX   PubMed=8468364; DOI=10.1002/jcp.1041550123;
RA   Leckett B., Spurmanis A., Allen C., Germinario R.J.;
RT   "Mutant cell line demonstrating a block in insulin and insulin-like
RT   growth factor type 1 (IGF-1) induced mitogenesis.";
RL   J. Cell. Physiol. 155:179-184(1993).
//