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Cellosaurus NP361-CDK4R24C-hTert (CVCL_B3Q4)

[Text version]
Cell line name NP361-CDK4R24C-hTert
Synonyms NP361CDK4R24C/hTert
Accession CVCL_B3Q4
Resource Identification Initiative To cite this cell line use: NP361-CDK4R24C-hTert (RRID:CVCL_B3Q4)
Comments Population: Chinese.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1773; CDK4 (Note=With p.Arg24Cys).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Pharynx, nasopharynx, epithelium; UBERON=UBERON_0001951.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_B3Q3 ! NP361hTert
CVCL_B3Q5 ! NP361-cyclinD1-hTert
Sex of cell Female
Age at sampling 50Y
Category Telomerase immortalized cell line
Publications

PubMed=23161911; DOI=10.1073/pnas.1202637109; PMCID=PMC3528537
Tsang C.-M., Yip Y.-L., Lo K.-W., Deng W., To K.-F., Hau P.-M., Lau V.M.-Y., Takada K., Lui V.W.-Y., Lung M.L., Chen H.-L., Zeng M.-S., Middeldorp J.M., Cheung A.L.-M., Tsao S.-W.
Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells.
Proc. Natl. Acad. Sci. U.S.A. 109:E3473-E3482(2012)

DOI=10.1016/B978-0-12-814936-2.00005-5
Yip Y.-L., Lin W.-T., Deng W., Tsang C.-M., Tsao S.-W.
Establishment of nasopharyngeal carcinoma cell lines, patient-derived xenografts, and immortalized nasopharyngeal epithelial cell lines for nasopharyngeal carcinoma and Epstein-Barr virus infection studies.
(In book chapter) Nasopharyngeal carcinoma. From etiology to clinical practice; Lee A.W.-M., Lung M.L., Ng W.T. (eds.); pp.85-107; Academic Press; New York; USA (2019)

Cross-references
Encyclopedic resources Wikidata; Q110433109
Entry history
Entry creation16-Dec-2021
Last entry update19-Dec-2024
Version number6